An enormous number of patients in Russia and worldwide are treated with highly toxic medications. Such therapy regimens are necessary, for example, for tuberculosis, oncological and other systemic and infectious diseases. Systemic intake of highly toxic medications (in the form of tablets for oral administration) is complicated by severe side effects.
The main programs of chemotherapy presuppose simultaneous intake of various medications. In this case, the concentration of active substance in each medication must be at a high level to achieve the desired therapeutic effect.
The practice of chemotherapy for tuberculosis and oncology shows that in the face of severe side effects, patients avoid, feign or refuse treatment. This causes the formation of multiple drug resistance and the need to use combinations of even more expensive and toxic medications to continue therapy.
It is impossible to calculate the accurate dose of the substance that got directly into the blood, and, therefore, the accurate therapy cannot be prescribed because of the individual characteristics of each person (low bioavailability in case of oral administration).
There is an alternative method for delivery of active substance - inhalation. Using this method, it is possible to significantly increase bioavailability and to avoid the harmful effects of chemicals on human organs and systems by delivering the active substance directly to the pulmonary circulation through the air vesicles (lower lungs).
Currently, the inhalation method is used to treat respiratory diseases. This is due to the fact that existing ultrasonic nebulizers are able to deliver particles of matter only to the upper lungs. Attempts to create an inhaler capable of delivering the active substance to the air vesicles were unsuccessful. Either the particles are too large and do not reach the alveolar region, or their concentration is so low that, in order to achieve the desired therapeutic effect, inhalation should last dozens of hours.